SERCA2a gene transfer improves electrocardiographic performance in aged mdx mice
نویسندگان
چکیده
منابع مشابه
Increased catalase expression improves muscle function in mdx mice.
It has been well established that oxidative stress contributes to pathology associated with Duchenne muscular dystrophy (DMD). I hypothesized that overexpression of the antioxidant enzyme catalase would improve muscle function in the mdx mouse, the mouse model of DMD. To test this hypothesis, neonatal mdx mice were injected with a recombinant adeno-associated virus driving the catalase transgen...
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Duchenne muscular dystrophy (DMD) is a fatal disease caused by defects in the gene encoding dystrophin. Dystrophin is a cytoskeletal protein, which together with its associated protein complex, helps to protect the sarcolemma from mechanical stresses associated with muscle contraction. Gene therapy efforts aimed at supplying a normal dystrophin gene to DMD muscles could be hampered by host immu...
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Haiying Pan (1,2), William Wang (1,4) , Kiley Murray (1,2), Mia Jefferson (1,2), Thomas Liu (2), Yong Li + (1-4) 1. The Laboratory of Molecular Pathology, Stem Cell Research Center, Children’s Hospital of UPMC; 2. Department of Orthopaedic Surgery, 3. Department of Pathology, 4. Dept. of Bioengineering, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213 + Senior author: yongli@p...
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Poloxamer 188 NF (national formulary (NF) grade of P-188) improves cardiac muscle function in the mdx mouse and golden retriever muscular dystrophy models. However in vivo effects on skeletal muscle have not been reported. We postulated that P-188 NF might protect diaphragm muscle membranes from contraction-induced injury in mdx and mdx/utrophin-/- (dko) muscular dystrophy models. In the first ...
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ژورنال
عنوان ژورنال: Journal of Translational Medicine
سال: 2011
ISSN: 1479-5876
DOI: 10.1186/1479-5876-9-132